期刊
IMMUNITY
卷 50, 期 4, 页码 907-923出版社
CELL PRESS
DOI: 10.1016/j.immuni.2019.03.025
关键词
-
类别
资金
- NIH [R01AI139512, DP2AI117922, R01AI073755, R01AI127828, R01HD091218]
Type I interferons (IFNs) (IFN-alpha,IFN-beta) and type III IFNs (IFN-lambda) share many properties, including induction by viral infection, activation of shared signaling pathways, and transcriptional programs. However, recent discoveries have revealed context-specific functional differences. Here, we provide a comprehensive review of type I and type III IFN activities, highlighting shared and distinct features from molecular mechanisms through physiological responses. Beyond discussing canonical antiviral functions, we consider the adaptive immune primin anti-tumor, and autoimmune functions of IFNs. We discuss a model wherein type III IFNs serve as a front-line defense that controls infection at epithelial barriers while minimizing damaging inflammatory responses, reserving the more potent type I IFN response for when local responses are insufficient. In this context, we discuss current therapeutic applications targeting these cytokine pathways and hignlignt gaps in understanding of the biology of type I and type III IFNs in health and disease.
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