期刊
IMMUNITY
卷 50, 期 4, 页码 778-795出版社
CELL PRESS
DOI: 10.1016/j.immuni.2019.03.012
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资金
- European Commission (ERC) [PHII-669415]
- Ministero dell'Istruzione, dell'Universita e della Ricerca (MIUR) [PRIN 2015YYKPNN]
- Italian Ministry of Health (Ricerca Finalizzata) [RF-2013-02355470]
Forty years after its naming, interleukin-1 (IL-1) is experiencing a renaissance brought on by the growing understanding of its context-dependent roles and advances in the clinic. Recent studies have identified important roles for members of the IL-1 family-IL-18, IL-33, IL-36, IL-37, and IL-38-in inflammation and immunity. Here, we review the complex functions of IL-1 family members in the orchestration of innate and adaptive immune responses and their diversity and plasticity. We discuss the varied roles of IL-1 family members in immune homeostasis and their contribution to pathologies, including autoimmunity and auto-inflammation, dysmetabolism, cardiovascular disorders, and cancer. The trans-disease therapeutic activity of anti-IL-1 strategies argues for immunity and inflammation as a metanarrative of modern medicine.
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