期刊
IEEE TRANSACTIONS ON BIOMEDICAL CIRCUITS AND SYSTEMS
卷 13, 期 2, 页码 292-313出版社
IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
DOI: 10.1109/TBCAS.2018.2886952
关键词
Computer-aided design (CAD); digital microfluidics; error recovery; micro-electrode-dot-array
资金
- U.S. National Science Foundation [CCF-1702596]
- Ministry of Science and Technology of Taiwan [MOST 105-2221-E-007-118-MY3, 104-2220-E-007-021]
- Technische Universitat Munchen Institute for Advanced Study through the German Excellence Initiative
- European Union [291763]
- Taiwan Ministry of Science and Technology [MOST 103-2221-E-009-191, 104-2218-E-009-007]
Digital microfluidic biochips (DMFBs) are being increasingly used for DNA sequencing, point-of-care clinical diagnostics, and immunoassays. DMFBs based on a micro-electrode-dot-array (MEDA) architecture have recently been proposed, and fundamental droplet manipulations, e.g., droplet mixing and splitting, have also been experimentally demonstrated on MEDA biochips. There can be thousands of microelectrodes on a single MEDA biochip, and the fine-grained control of nanoliter volumes of biochemical samples and reagents is also enabled by this technology. MEDA biochips offer the benefits of real-time sensitivity, lower cost, easy system integration with CMOS modules, and full automation. This review paper first describes recent design tools for high-level synthesis and optimization of map bioassay protocols on a MEDA biochip. It then presents recent advances in scheduling of fluidic operations, placement of fluidic modules, droplet-size-aware routing, adaptive error recovery, sample preparation, and various testing techniques. With the help of these tools, biochip users can concentrate on the development of nanoscale bioassays, leaving details of chip optimization and implementation to software tools.
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