期刊
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
卷 41, 期 9, 页码 2904-2913出版社
WILEY
DOI: 10.1002/hed.25763
关键词
apoptosis; immunohistochemistry; mucoepidermoid carcinoma; proliferation; salivary gland tumors
资金
- São Paulo Research Foundation (FAPESP) [11/02051-6, 12/20734-6, 12/09759-7] Funding Source: Medline
- Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [12/09759-7] Funding Source: FAPESP
Background Mucoepidermoid carcinoma is the most common malignant tumor of salivary glands. Apoptosis plays an important role in organogenesis of glandular structures, and aberrations of apoptotic mechanisms is associated with a wide array of pathologic conditions. Methods The immunoexpression of proteins associated with apoptosis and proliferation was evaluated in 40 mucoepidermoid carcinoma cases. Results Par-4, Survivin, MUC1, PHLDA1, Fas, and Ki-67 were predominantly expressed in mucoepidermoid carcinoma. FasL was rarely expressed, and Caspase-3 expression was observed in almost 50% of the cases. SPARC expression was associated with low-grade tumors, and Ki-67 expression was associated with lymph node metastasis. Expression of Fas and decreased expression of Ki-67 and Caspase-3 were associated with better overall cancer-specific survival rates. Conclusions The association of SPARC and Ki-67 expression with pathological features and the association of Fas, Caspase-3, and Ki-67 with survival probabilities suggest that these proteins may be useful prognostic markers for mucoepidermoid carcinoma.
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