期刊
BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION
卷 21, 期 12, 页码 2069-2078出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.bbmt.2015.08.038
关键词
GVHD; Bone marrow transplantation; T cells
资金
- Deutsche Forschungsgemeinschaft [KO 3582/3-1, SFB738-A8, SFB900-B8, BE 1886/2-3, SFB738-B5]
Homing of allogeneic donor T cells to recipient tissue is imperative for the development of acute graft-versus-host disease (GVHD) after bone marrow transplantation (BMT). In this study we show that alteration of T cell homing due to integrin-beta 7 deficiency on T cells or its ligand MAdCAM-1 in BMT recipients contributes to the pathophysiology of experimental GVHD. In contrast, lack of CC chemokine receptor 9 on donor T cells alters tissue homing but does not impact GVHD survival. We further demonstrate that MAdCAM-1 is aberrantly expressed in hepatic murine GVHD as well as in patients with active liver GVHD. However, infiltration of donor T cells in gut but not liver was dependent of MAdCAM-1 expression, indicating, that homing and/or retention of donor T cells rests on divergent molecular pathways depending on the GVHD target tissue. (c) 2015 American Society for Blood and Marrow Transplantation.
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