期刊
ANNALS OF MEDICINE
卷 48, 期 6, 页码 456-467出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/07853890.2016.1193786
关键词
Developmental Origins of Health and Disease; fetal growth; childhood growth; programming; Helsinki Birth Cohort Study (HBCS)
资金
- British Heart Foundation
- NIH
- Finska Lakaresallskapet
- Finnish Special Governmental Subsidy for Health Sciences
- Academy of Finland
- Samfundet Folkhalsan
- Liv och Halsa
- Juho Vainio Foundation
- Yrjo Jahnsson Foundation
- Diabetes Research Foundation
- Finnish Foundation for Cardiovascular Research
- Signe and Ane Gyllenberg Foundation
- EU FP7 (DORIAN) [278603]
- EU Horizon (DynaHealth) project [633595]
The Developmental Origins of Health and Disease (DOHaD) hypothesis proposes that several non-communicable diseases have their origins in prenatal life and in early childhood. This is believed to work through programming, an insult, taking place at a sensitive period of development, may have lifelong consequences, increasing and programming disease risk later in life. The Helsinki Birth Cohort Study (HBCS) has been focusing upon the importance of factors active during periods in early life and their influence on later health in 20,431 people born 1924-44. This review will focus upon findings from the HBCS over the past 20 years. Early growth patterns associated with coronary heart disease, type 2 diabetes and other health outcomes are described. The long-term health impact of maternal adiposity is also discussed. Potential underlying mechanisms explaining the associations are discussed including epigenetic factors.Key messagesSeveral non-communicable diseases - including coronary heart disease and type 2 diabetes - have their origins in early life.Early life programming during sensitive periods of development may permanently program future health and disease risk.Optimizing the health and lifestyle of women of reproductive age will have positive health consequences for their offspring.
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