期刊
FITOTERAPIA
卷 134, 期 -, 页码 372-377出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.fitote.2019.03.010
关键词
Trichoderma asperellum; Sesquiterpene; Norsesquiterpene; Bisabolane
资金
- National Natural Science Foundation of China [31670355]
- Natural Science Foundation for Distinguished Young Scholars of Shandong Province [JQ201712]
- Key Cutting Edge Research Program of the Chinese Academy of Sciences [QYZDB-SSW-DQC013]
- Youth Innovation Promotion Association of CAS [2013138]
- Science and Technology Service Network Initiative of CAS [KFJ-STS-ZDTP-023]
Eight new bisabolane derivatives, trichobisabolins A-H, along with two known ones, (3R,6R,7R)-1,10-bisaboladien-3-ol (9) and (3R,6R,7S)-1,10-bisaboladien-3,6-diol (10) were isolated from the culture of Trichoderma asperellum Y6-2, obtained from the surface of the marine red alga Chondrus ocellatus. Their structures and relative configurations were identified by interpretation of 1D/2D NMR and MS data. Compounds 1-8 were assayed for inhibiting the growth of some marine-derived organisms, including four marine phytoplankton species, one marine zooplankton species, and five pathogenic bacteria. All of them exhibited inhibition against the marine phytoplanktons with IC50 values ranging from 2.1-78 mu g/mL, compounds 4 and 8 showed weak lethality to the marine zooplankton, and none of them had inhibition against the five pathogenic bacteria.
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