期刊
FARMACIA
卷 67, 期 3, 页码 477-481出版社
SOC STIINTE FARMACEUTICE ROMANIA
DOI: 10.31925/farmacia.2019.3.15
关键词
Alzheimer's dementia; cognitive therapy; MMSE; memantine; donepezil
We have studied the effects of various combinations of specific drug therapies on patients with Alzheimer's dementia. The study was conducted over a 12-week period, with initial, after 4, 8, and 12-weeks assessment. A number of 140 patients with Alzheimer's dementia were assessed observing the clinical manifestations, the therapeutic measures that were applied and the changes in the response to treatment. Mini-Mental State Examination (MMSE) was used to monitor the cognitive functionality evolution of the studied patients. The depreciation of the MMSE score was observed in 2.94% of the patients registering a mild impairment, in 6.02% - a moderate impairment and 17.39% - a severe impairment. The greatest depreciation effect was achieved with memantine in monotherapy (ES = 0.24), and the lowest - with donepezil therapy in combination with memantine (ES = 0.24). Our results prove that specific anti-dementia treatment is effective for the treatment of cognitive impairment, especially if it is instituted at the onset of the disease.
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