期刊
EXPERIMENTAL GERONTOLOGY
卷 119, 期 -, 页码 146-156出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.exger.2019.02.006
关键词
Aging; Environmental stress; Longevity; Marine; Pollution; Proteolytic activity
资金
- US National Science Foundation [IOS1154321]
- National Institute on Aging of the US National Institutes of Health [R21AG055873, AG052374]
- Genomics and Geology Undergraduate Research Experience Program at the University of Southern California (USC)
- University Research Associate Program Fellowships at USC
- National Science Foundation Research Experience for Undergraduates [OCE1263356]
- National Institute of Environmental Health Sciences of the US National Institutes of Health [ES003598]
- National Science Foundation [DEB1656048]
Because stress tolerance and longevity are mechanistically and phenotypically linked, the sex with higher acute stress tolerance might be expected to also live longer. On the other hand, the association between stress tolerance and lifespan may be complicated by tradeoffs between acute tolerance and long-term survival. Here we use the copepod Tigriopus californicus to test for sex differences in stress resistance, proteolytic activity and longevity. Unlike many model organisms, this species does not have sex chromosomes. However, substantial sex differences were still observed. Females were found to have superior tolerance to a range of acute stressors (high temperature, high salinity, low salinity, copper and bisphenol A (BPA)) across a variety of treatments including different populations, pure vs. hybrid crosses, and different shading environments. Upregulation of proteolytic capacity - one molecular mechanism for responding to acute stress - was also found to be sexually dimorphic. In the combined stress treatment of chronic copper exposure followed by acute heat exposure, proteolytic capacity was suppressed for males. Females, however, maintained a robust proteolytic stress response. While females consistently showed greater tolerance to short-term stress, lifespan was largely equivalent between the two sexes under both benign conditions and mild thermal stress. Our findings indicate that short-term stress tolerance does not predict long-term survival under relatively mild conditions.
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