期刊
EXPERIMENTAL GERONTOLOGY
卷 118, 期 -, 页码 31-38出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.exger.2019.01.002
关键词
Myofascial pain syndrome; Osteoarthritis; Neurogenic inflammation; Substance P; Central sensitization
资金
- Natural Sciences and Engineering Research Council of Canada (NSERC) [301 029900]
- Brazilian National Council for Scientific and Technological Development (CNPq-Brazil) [202155/2014-5]
Objective: This study aimed to investigate the association between naturally occurring spinal osteoarthritis (OA) (L3-L5), the expression of substance P (SP) centrally (L4-L5) and the presence of neurogenic inflammation within the neurosegmentally linked quadriceps (L2-L5) in elderly rats versus young controls. Design: Eight aged (27 +/- 3.2 months) and six young (4 +/- 0.0 months) male Wistar Kyoto rats were euthanized and submitted to micro-computerized tomography for determination of spine OA. SP expression (% area) at the dorsal horn of the spinal cord as well as the relative expression of SP and protease-activated receptor 2 (PAR2) to alpha-tubulin within quadriceps muscle were determined by immunohistochemistry and Western Blot. Results: Spine osteoarthritis was confirmed in all aged rats but no young controls. Aged rats expressed significant increase of SP protein expression within the dorsal horn (MD = 0.086; 95% CI [0.026 to 0.145]; p = 0.0094) and quadriceps (MD = 1.209; 95% CI [0.239 to 2.179]; p = 0.0191) and PAR2 (MD = 0.797; 95% CI [0.160 to 1.435]; p = 0.0187) compared to young controls. Conclusion: These observations provide novel insight into the potential role of neurogenic inflammation in the pathophysiology of myofascial pain syndrome in the naturally occurring spinal OA in elderly population.
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