期刊
EXERCISE AND SPORT SCIENCES REVIEWS
卷 47, 期 2, 页码 98-107出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1249/JES.0000000000000184
关键词
type 1 diabetes; aging; skeletal muscle health; atrophy; metabolism; muscle strength; mitochondrial dysfunction
资金
- Natural Sciences and Research Engineering Council of Canada [436128-2013]
- James H. Cummings Foundation
- Natural Sciences and Engineering Research Council [298738-2013, RGPIN-2018-6324]
Recent evidence reveals impairments to skeletal muscle health in adolescent/young adults with type 1 diabetes (T1D). Interestingly, the observed changes in T1D are not unlike aged muscle, particularly, the alterations to mitochondria. Thus, we put forth the novel hypothesis that T1D may be considered a condition of accelerated muscle aging and that, similar to aging, mitochondrial dysfunction is a primary contributor to this complication.
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