期刊
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
卷 2019, 期 18, 页码 2928-2932出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ejoc.201900383
关键词
Aspergillus terreus; Alkaloids; Natural products; Structure elucidation; Antibacterial activity
资金
- Changjiang Scholars of Ministry of Education of the People' s Republic of China [T2016088]
- National Natural Science Foundation for Distinguished Young Scholars [81725021]
- Innovative Research Groups of the National Natural Science Foundation of China [81721005]
- National Natural Science Foundation of China [81573316, 21702067, 81803387]
- Hubei Provincial Natural Science Foundation of China [2018CFB152]
Asperteramide A, an unusual N-phenyl-carbamic acid methyl ester trimer, was isolated and identified from the coral-derived fungus Aspergillus terreus. The deceptive and indistinguishable NMR signals caused by three N-phenyl-carbamic acid methyl ester subunits located in different spatial environments created great challenge for the identification of its planar structure, but recrystallization ultimately afforded a suitable crystal for the X-ray diffraction experiment, which enabled its final structure determination. The plausible biosynthetic pathway of 1 mainly involved in the successive Friedel-Crafts reactions. Additionally, compound 1 showed significant antibacterial activity against seven microbial pathogens [ESBL-producing Escherichia coli, Acinetobacter baumannii, Pseudomonas aeruginosa, Klebsiella pneumoniae, methicillin-resistant Staphylococcus aureus, Enterococcus faecalis, Candida albicans] with MIC values ranging from 2 to 64 mu g/mL.
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