4.5 Article

Non-Macrocyclic Schiff Base Complexes of Iron(II) as ParaCEST Agents for MRI

期刊

EUROPEAN JOURNAL OF INORGANIC CHEMISTRY
卷 -, 期 19, 页码 2404-2411

出版社

WILEY-V C H VERLAG GMBH
DOI: 10.1002/ejic.201801565

关键词

ParaCEST; Iron; Imaging agents; Acidity; Structure elucidation

资金

  1. Spectroscopy Society of Pittsburgh

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Nearly two decades of research efforts have been devoted to paramagnetic chemical exchange saturation transfer (paraCEST) to produce image contrast in magnetic resonance imaging. Less than twenty iron-based paraCEST agents have been reported so far, the majority of which are ligated by macrocyclic chelates. In the work presented here three isostructural tripodal ligands sharing a common tris-(aza-butenyl)amine foundation are explored to further diversify iron-based paraCEST agents. One of the complexes provides contrast with a CEST effect of 33 % for a 10 mm sample, a paramagnetic shift (Delta omega) of 85 ppm from bulk H2O, and exhibits some stability to biologically relevant ions.

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