期刊
EUROPEAN JOURNAL OF CELL BIOLOGY
卷 98, 期 5-8, 页码 -出版社
ELSEVIER GMBH
DOI: 10.1016/j.ejcb.2019.04.002
关键词
Mesenchymal stem cells; Inflammatory diseases; Immunomodulation
类别
资金
- National Research Foundation (NRF) of Korea - Korean Ministry of Science, ICT, and Future Planning [2015R1A5A2009124, 2017R1D1A1B03027831]
- Korea Health Industry Development Institute (KHIDI) - Ministry of Health and Welfare, Republic of Korea [HI18C0453]
- Creative Economy Leading Technology Development Program of the Gyeongsangbuk-do and Gyeongbuk Science & Technology Promotion Center [SF316001A]
- National Research Foundation of Korea [2017R1D1A1B03027831] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Mesenchymal stem cells (MSCs) are promising alternative agents for the treatment of inflammatory disorders due to their immunomodulatory functions, and several clinical trials on MSC-based products are currently being conducted. In this review, we discuss recent progress made on the use of MSCs as immunomodulatory agents, developmental challenges posed by MSC-based therapy, and the strategies being used to overcome these challenges. In this context, current understanding of the mechanisms responsible for MSC interactions with the immune system and the molecular responses of MSCs to inflammatory signals are discussed. The immunosuppressive activities of MSCs are initiated by cell-to-cell contact and the release of immuno-regulatory molecules. By doing so, MSCs can inhibit the proliferation and function of T cells, natural killer cells, B cells, and dendritic cells, and can also increase the proliferation of regulatory T cells. However, various problems, such as low transplanted cell viability, poor homing and engraftment into injured tissues, MSC heterogeneity, and lack of adequate information on optimum MSC doses impede clinical applications. On the other hand, it has been shown that the immunomodulatory activities and viabilities of MSCs might be enhanced by 3D-cultured systems, genetic modifications, preconditioning, and targeted-delivery.
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