期刊
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
卷 67, 期 -, 页码 79-86出版社
ELSEVIER
DOI: 10.1016/j.etap.2019.02.004
关键词
Arsenic; Cardiovascular diseases; Epigenetic mechanisms; miR-126; miR-155; Mexico
资金
- CONACyT [CONACyT- PDCPN2015-1558]
The aim of this research was to investigate circulating expression levels of three miRNAs (miR-126, miR-155, and miR-145) proposed as predictive CVD biomarkers in Mexican women exposed to inorganic arsenic via drinking water. Mean UAs concentration of 19.5 +/- 14.0 mu g/g creatinine was found after urine samples were analyzed (n = 105). Significant associations between UAs levels and serum expression levels of miR-155 (p < 0.05) and miR-126 (p < 0.05) were observed after adjustment for assessed co-variables. Alterations in the serum expression levels of miR-155 and miR-126 may be associated with the onset and development of cardiovascular diseases, hence miRNAs could be proposed as prognostic CVD biomarkers. Data found in this study are of concern and risk reduction plans are necessary for the assessed communities to prevent cardiovascular events in this population of women.
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