Short-term joint effects of ambient air pollutants on emergency department visits for respiratory and circulatory diseases in Colombia, 2011-2014

Background: We evaluated the short-term effect of mixtures of ambient air pollutants on respiratory and circulatory morbidity in four Colombian cities. Methods: Daily Emergency Department (ED) visit records for respiratory and circulatory selected diagnosis and daily concentrations for six criteria air pollutant were obtained in four of the five major cities in Colombia: Bucaramanga, Bogota, Cali, and Medellin during nu 2014. Using conditional Poisson time series analysis with fixed effects, we assessed the effect of air pollutants on health outcomes using single pollutant, two-pollutant and specific mixtures-of-pollutant models controlling for meteorology and time trends. The percentages of change in the rate of ED visits and their 95% confidence interval were estimated for the joint effect of pollutants. Results: In single-pollutant models increases in gases concentrations were associated with increases in ED visits for respiratory and circulatory diseases. The two-pollutant models for respiratory diseases showed that the effect of NO2 alone (% change 2.86 95% CI 1.87-3.85) is higher than the joint effect of any of its combinations except for its combination with SO2 (% change 3.05 95%Cl 1.04-5.05). The two-pollutant models for circulatory diseases showed synergistic effects between NO2 and PM2.5 (% change 2.13 95%CI 0.001-4.26). Specific mixtures models showed that the mixture of traffic-related pollutants has the higher joint effect on circulatory morbidity and respiratory morbidity. Conclusions: The results show the dominant effect of NO2 in air pollution mixtures on respiratory and circulatory morbidity, and the synergistic effect of NO2 and SO2 in air pollution mixtures on respiratory morbidity. (C) 2019 Elsevier Ltd. All rights reserved.