期刊
EJSO
卷 45, 期 8, 页码 1460-1467出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.ejso.2019.03.042
关键词
Best supportive care; Hepatocellular carcinoma; Portal vein tumor thrombus; Transarterial chemoembolization
资金
- National Natural Science Foundation of China [81570590, 81872508]
- Graduate Course Construction Project of Guangxi Medical University [YJSA2017014]
- Foundation Ability Enhancement Project for Young Teachers in Guangxi Universities [2018KY0122]
- National Major Special Science and Technology Project [2017ZX10203207]
- Self-Raised Scientific Research Fund of the Ministry of Health of Guangxi Province [Z2016479]
- Guangxi BaGui Young Scholars
Background: This study aims to compare the efficacy and safety of treatment after transarterial chemoembolization(TACE) with best supportive care (BSC) in patients with hepatocellular carcinoma (HCC) with PVTT. Methods: This retrospective study was conducted on 1,040 patients with HCC with PVTT who were treated either with TACE (n = 675) or BSC (n = 365). BSC did not include sorafenib. The two groups of patients were compared with or without propensity score matching. A subgroup analysis was subsequently performed by stratifying patients according to the stages of PVTT in the Cheng's PVTT classification. Results: In PVTTtypes I-III, TACE was associated with significantly better overall survival (OS) thanBSC (P < 0.05). Within each type of PVTT for patients who received TACE or BSC, OS was significantly worse in patients with type IVPVTT than in any of the other three types of PVTT (all P < 0.05). TACE was associated with better long-termOS than BSC after propensity score matching or on stratification by the PVTT types. Conclusion: TACE was associated with better OS than BSC in HCC patients with pm types I-Ill but not type IV. Patients with type IV PVTT showed the worst prognosis, regardless of whether TACE or BSC was used. (C) 2019 Elsevier Ltd, BASO similar to The Association for Cancer Surgery, and the European Society of Surgical Oncology. All rights reserved.
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