期刊
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
卷 173, 期 -, 页码 192-202出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.ecoenv.2019.01.114
关键词
Bisphenol S; Occurrence in environment; Human exposure; Toxicity mechanism; Estrogen receptor
资金
- National Key R&D Program of China [2018YFC0406504]
- National Natural Science Foundation of China [21707064, 21507055]
- State Environmental Protection Key Laboratory of Integrated Surface Water-Groundwater Pollution Control, Guangdong Provincial Key Laboratory of Soil and Groundwater Pollution Control [2017B030301012]
- Shenzhen Municipal Science and Technology Innovation Committee [KQTD2016022619584022, ZDSY20150831141712549, ZYTS20180208164537559]
- Southern University of Science and Technology [G01296001]
- Leading Talents of Guangdong Province Program (Chunmiao Zheng)
Bisphenol S (BPS) has been introduced into the industry as a safer alternative to bisphenol A (BPA). The distribution of BPS has recently become an important issue worldwide, but investigations on the toxicity and mechanisms of BPS remain limited. A review of the literature reveals that BPS has widespread presence in environmental media, such as indoor dust, surface water, sediments, and sewage sludge. It has been detected in plants, paper products, some food items, and even in the human body. In addition, compared to BPA, BPS has a lower acute toxicity, similar or less endocrine disruption, similar neurotoxicity and immunotoxicity, and lower reproductive and developmental toxicity. The mechanisms underlying BPS toxicity may be related to the chemical properties of BPS in the human body, including interactions with estrogen receptors, and binding to DNA and some proteins, subsequently including exerting oxidative stress. However, further investigation on the potential risks of BPS to humans and its mechanisms of toxicity should be conducted to better understand and control the risks of such novel chemicals.
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