期刊
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
卷 172, 期 -, 页码 11-18出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.ecoenv.2019.01.061
关键词
Carbamazepine; Daphnia magna; Bioconcentration; Feeding behavior; Phototactic behavior; Biomarker
资金
- National Natural Science Foundation of China [51879228]
- National Science Funds for Creative Research Groups of China [51421006]
- Fundamental Research Funds for the Central Universities [2018B43614]
- Program for Scientific Research Innovation Team in Colleges and Universities of Tibet Autonomous Region
- Priority Academic Program Development of Jiangsu Higher Education Institutions
Owing to its persistence, carbamazepine an antiepileptic drug is regularly detected in the aquatic environment. The motive for our research was to assess the bioconcentration, physiological and biochemical effects of carbamazepine in Daphnia magna. A 48 h aqueous exposure of carbamazepine yielded bioconcentration factors of 202.56 and 19.95 in Daphnia magna for the respective nominal treatments of 5 and 100 mu g/L. Apparently, the inhibition of the capability of Daphnia magna to obtain food attributable to carbamazepine exposure will reduce their fitness to reproduce as well as to grow. Also, a significant alteration in the phototactic behaviour of Daphnia magna exposed to carbamazepine is maladaptive since it will increase their chance of being preyed upon in the surface water during daylight. Again, a significant decline in the acetylcholinesterase activity observed herein brings to light the neurotoxicity of carbamazepine to Daphnia magna. Moreover, significant inhibition of the superoxide dismutase, catalase and glutathione reductase activities coupled with the simultaneous induction of the malondialdehyde content imply that carbamazepine evoked a life-threatening oxidative stress that overpowered the antioxidant defence system of Daphnia magna. These observations confirm that carbamazepine can accumulate and consequently cause negative physiological and biochemical changes to wild Daphnia magna populations.
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