4.5 Article

Population impact of preterm birth and low birth weight on developmental disabilities in US children

期刊

ANNALS OF EPIDEMIOLOGY
卷 26, 期 4, 页码 267-274

出版社

ELSEVIER SCIENCE INC
DOI: 10.1016/j.annepidem.2016.02.012

关键词

Developmental disabilities; Premature birth; Infant; Low birth weight; Risk factor

资金

  1. Intramural CDC HHS [CC999999] Funding Source: Medline

向作者/读者索取更多资源

Purpose: Although previous studies demonstrate associations between adverse perinatal outcomes and developmental disabilities (DDs), study of population impacts is limited. Methods: We computed relative risks adjusted (aRRs) for sociodemographic factors and component and summary population attributable fractions (PAFs) for associations between very low birth weight (VLBW, all preterm births), moderately low birth weight (MLBW) + Preterm, MLBW at term, and normal birth weight (NBW) + Preterm and seven DDs (cerebral palsy [CP], autism spectrum disorder [ASD], intellectual disability [ID], behavioral-conduct disorders, attention-deficit-hyperactivity disorder [ADHD], learning disability [LD], and other developmental delay) among children aged 3-17 years in the 2011 2012 National Survey of Children's Health. Results: VLBW-Preterm, MLBW-Preterm and NBW-Preterm were strongly to moderately associated with CP (aRRs: 43.5, 10.1, and 22, respectively; all significant) and also associated with ID, ASD, LD, and other developmental delay (aRR ranges: VLBW-Preterm 2.8-5.3; MLBW-Preterm 1.9-2.8; and NBW-Preterm 1.6-2.3). Summary PAFs for preterm birth and/or LBW were 55% for CP, 10%-20% for ASD, ID, LD, and other developmental delay, and less than 5% for ADHD and behavioral-conduct disorders. Findings were similar whether we assessed DDs as independent outcomes or within mutually exclusive categories accounting for DD co-occurrence. Conclusions: Preterm birth has a sizable impact on child neurodevelopment. However, relative associations and population impacts vary widely by DD type. (C) 2016 Elsevier Inc. All rights reserved.

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