期刊
DRUG DISCOVERY TODAY
卷 24, 期 6, 页码 1295-1303出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.drudis.2019.04.003
关键词
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资金
- Neurological Foundation of New Zealand
- Health Research Council of New Zealand
- Biochemical Society
- University of Auckland
- School of Chemical Sciences, The University of Auckland
Parkinson's disease (PD) is one of the most common neurodegenerative disorders. The exact cause(s) of PD is not well understood, although genetic mutations are associated with some forms of the disease. Many of these mutations, in particular those that are found in LRRK2, DJ-1, PINK1, and Parkin, are linked to the deregulation of mRNA translation, suggesting that this process is important for the onset of PD. Herein, we highlight recent studies that provide insights into the molecular mechanisms that relate mRNA translation to PD. These studies confirm the central role of translation in PD, emphasising the potential of restoring mRNA translation functionality as a new therapeutic treatment against PD, and providing novel targets for developing new chemical agents to target this disease.
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