期刊
DNA REPAIR
卷 76, 期 -, 页码 60-69出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.dnarep.2019.02.006
关键词
Oxidative stress; DNA damage; Oxidation of DNA repair proteins; Double strand break repair; Base excision repair
资金
- National Cancer Institute [CA080830]
Reactive oxygen and nitrogen species (RONS) are formed as byproducts of many endogenous cellular processes, in response to infections, and upon exposure to various environmental factors. An increase in RONS cart saturate the antioxidation system and leads to oxidative stress. Consequently, macromolecules are targeted for oxidative modifications, including DNA and protein. The oxidation of DNA, which leads to base modification and formation of abasic sites along with single and double strand breaks, has been extensively investigated. Protein oxidation is often neglected and is only recently being recognized as an important regulatory mechanism of various DNA repair proteins. This is a review of the current state of research on the regulation of DNA repair by protein oxidation with emphasis on the correlation between inflammation and cancer.
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