期刊
ANNALS OF EPIDEMIOLOGY
卷 26, 期 11, 页码 764-772出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.annepidem.2016.09.006
关键词
Type 2 diabetes; Liver cancer; Meta-analysis; Cohort study
资金
- Shanghai Jiao Tong University [YG2012MS37]
Purpose: Questions remain uncertainty regarding the gender differences in the relationship between type 2 diabetes (T2DM) and liver cancer risk. By considering several confounding factors, we aimed to identify this issue according to a meta-analysis of cohort studies. Methods: We searched EMBASE and MEDLINE for studies on the association between T2DM and risk of liver cancer up to November 30, 2014. A random-effects model was performed to calculate summary relative risks (SRRs) with corresponding 95% confidence intervals (CIs). Results: A total of 24 cohort studies (including more than 20,000 liver cancer cases) were recruited.T2DM was associated with an elevated liver cancer incidence in both men (SRR = 2.16; 95% CI, 1.74-2.69) and women (SRR = 1.85; 95% CI, 1.40-2.44). Stratified analyses showed that the risk associations were significantly stronger in non-Asian than those in Asian for both men and women. Both tobacco smoking and body mass index were significant confounding factors for the T2DM-liver cancer association in men, whereas alcohol use was not the case. The SRR estimates of liver cancer mortality with T2DM were statistically significant in both men and women (men: SRR = 2.26; 95% CI, 1.60-3.19 and women: SRR = 2.01; 95% Cl, 1.45-2.74). Conclusions: Results of this meta-analysis indicate that the T2DM-liver cancer correlation is confounded by smoking and body mass index in both men and women. Results also suggest a significantly stronger T2DM-liver cancer correlation in non-Asian than that in Asian for both men and women. (C) 2016 Elsevier Inc. All rights reserved.
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