期刊
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE
卷 95, 期 2, 页码 179-184出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.diagmicrobio.2019.05.006
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The aim of this cross-sectional study was to investigate associations between salivary active matrix-metalloproteinase 8 (aMMP-8) and periodontitis severity, potentially periodontal pathogenic bacteria as well as blood parameters in generally healthy participants. Therefore, 188 participants with a mean age of 48.9 +/- 8 years were examined. The periodontitis severity was assessed based on periodontal probing depth and clinical attachment loss. Both, aMMP-8 and microbiological analysis were performed using a validated, commercially available test system. Blood values were utilized from regular differential blood count. The aMMP-8 findings were associated with the periodontitis severity (P < 0.01), as well as with the prevalence of Porphyromonas gingivalis, Tannerella forsythia, Prevotella intermedia, Parvimonas micro, Camphylobacter rectus and Eubacterium nodatum (P-i < 0.05). No associations between aMMP-8 and the examined blood parameters were. found (P-i > 0.05). In conclusion, salivary aMMP-8 findings seem to reflect periodontal disease severity as a result of an immunoreaction, especially against bacteria with high periodontal pathogenic potential. (C) 2019 Elsevier Inc. All rights reserved.
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