期刊
DEVELOPMENTAL CELL
卷 49, 期 3, 页码 347-360出版社
CELL PRESS
DOI: 10.1016/j.devcel.2019.04.011
关键词
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资金
- National Cancer Institute [CA169538, CA169416]
- Department of Defense [W81XWH-13-1-0427, W81XWH-13-1-0249, W81XWH-14-1-0199]
- Manning Foundation
- Sohn Foundation
- STARR Consortium
- Nancy C. and Daniel P. Paduano Foundation
- James Paduano Foundation
- Alex's Lemonade Stand Foundation
- Daedalus Fund
- Scott and Lisa Stewart Foundation
- Malcolm Hewitt Wiener Foundation
- Thompson Family Foundation
- Children's Cancer and Blood Foundation
- Hartwell Foundation
- POETIC Consortium
Metastasis, a critical phase of tumor progression, remains a primary challenge in treating cancer and a major cause of cancer mortality. Cell-cell communication via extracellular vesicles (exosomes and microvesicles) between primary tumor cells and the microenvironment of distant organs is crucial for pre-metastatic niche (PMN) formation and metastasis. Here, we review work on the contribution of exosome cargo to cancer progression, the role of exosomes in PMN establishment, and the function of exosomes in organotropic metastasis. We also describe the clinical utility of exosomes.
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