期刊
DEVELOPMENT
卷 146, 期 9, 页码 -出版社
COMPANY BIOLOGISTS LTD
DOI: 10.1242/dev.178087
关键词
GATAe; Drosophila; Malpighian tubules; Principal and stellate cells; Renal stem cells; Proliferation; Maintenance; Migration
资金
- European Union's Horizon 2020 research and innovation program under the Marie Sklodowska-Curie grant [64293 RENALTRACT]
- BBSRC [BB/P008097/1] Funding Source: UKRI
The GATA family of transcription factors is implicated in numerous developmental and physiological processes in metazoans. In Drosophila melanogaster, five different GATA factor genes (pannier, serpent, grain, GATAd and GATAe) have been reported as essential in the development and identity of multiple tissues, including the midgut, heart and brain. Here, we present a novel role for GATAe in the function and homeostasis of the Drosophila renal (Malpighian) tubule. We demonstrate that reduced levels of GATAe gene expression in tubule principal cells induce uncontrolled cell proliferation, resulting in tumorous growth with associated altered expression of apoptotic and carcinogenic key genes. Furthermore, we uncover the involvement of GATAe in the maintenance of stellate cells and migration of renal and nephritic stem cells into the tubule. Our findings of GATAe as a potential master regulator in the events of growth control and cell survival required for the maintenance of the Drosophila renal tubule could provide new insights into the molecular pathways involved in the formation and maintenance of a functional tissue and kidney disease.
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