期刊
CURRENT OPINION IN CHEMICAL BIOLOGY
卷 49, 期 -, 页码 25-32出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.cbpa.2018.09.004
关键词
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资金
- National Institute of Health [1R35GM128895]
- Scripps Research Institute
Direct functionalization of C-H bond is rapidly becoming an indispensible tool in chemical synthesis. However, due to the ubiquity of C-H bonds, achieving site-selective functionalization remains an arduous task, especially on advanced synthetic intermediates or natural products. In contrast, Nature has evolved a multitude of enzymes capable of performing this task with extraordinary selectivity, and the use of these enzymes in organic synthesis may provide a viable solution to contemporary challenges in site-selective functionalization of complex molecules. This review covers recent applications of enzymatic C-H functionalization strategies in natural product synthesis, both in the context of key building block preparation and late-stage functionalization of advanced synthetic intermediates.
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