The quest for transcriptional hubs of lignin biosynthesis: beyond the NAC-MYB-gene regulatory network model

Lignin is an important secondary metabolite in plants. The biosynthesis of lignin is initiated by the transcriptional upregulation of genes encoding enzymes involved in monolignol biosynthesis and lignin polymerization. Based on studies of xylem differentiation over the last two decades, the NAC-MYB-based gene regulatory network (NAC-MYB-GRN) model is widely considered to underpin developmental lignin biosynthesis. We are now standing on the threshold of a new direction in transcriptional regulation research; the search for novel molecular hubs connecting developmental/environmental signals in lignin biosynthesis. Emerging genome-wide 'omits' technologies are a promising approach for understanding such hubs. Elucidating these molecular hubs may enable us to control lignification in harmony with plant development and environmental adaptation.