期刊
CURRENT OPINION IN BIOTECHNOLOGY
卷 56, 期 -, 页码 250-257出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.copbio.2019.02.017
关键词
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资金
- Center for Bioenergy Innovation (CBI), a U.S. Department of Energy (DOE) Bioenergy Research Center - Biological and Environmental Research in the DOE Office of Science
Population-level studies enabled by high-throughput phenotyping have revealed significant variation in lignin characteristics including content, S:G:H ratio, inter-unit linkage distributions, and molecular weights across multiple plant species. Coupled with genome-wide association mapping studies (GWAS) targeted at linking genetic mutations to phenotype, significant progress has been made in associating putative causal mutations to variation in lignin characteristics. Despite this progress, there are few examples, in which these associations have been molecularly validated to provide new insights into the genetic regulation of lignin biosynthesis. Given a recent report of a GWAS-discovered 5-enolpyruvylshikimate-3-phosphate (EPSP) synthase moonlighting as a transcriptional regulator of lignin biosynthesis, the potential to bridge scientific disciplines in order to uncover hidden elements of lignin biosynthesis has been demonstrated, offering a path to alter lignin characteristics via genetic manipulation in order to expedite lignin valorization. To maximize this potential, however, there is a crucial need for (1) broader surveys of naturally varying diverse plant populations and (2) analytical platforms that can resolve subtle properties at fine chemical and biological scales.
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