期刊
CURRENT BIOLOGY
卷 29, 期 9, 页码 1436-+出版社
CELL PRESS
DOI: 10.1016/j.cub.2019.03.048
关键词
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资金
- Research Foundation Flanders (FWO), Belgium [G0D7516N]
- KU Leuven, Belgium [C14/17/042]
Offline replay of hippocampal neural patterns supports the acquisition of new tasks in novel contexts, but its contribution to consolidation of salient experiences in a familiar context is unknown. Here, we show that in a highly familiar spatial memory task, large rewards selectively enhanced performance for demanding task configurations. The reward-related enhancement was sensitive to ripple-specific disruption, and the proportion of replay events positively correlated with reward size and task demands. Hippocampal replay thus selectively enhances memory of highly rewarded locations in a familiar context.
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