期刊
CRITICAL REVIEWS IN MICROBIOLOGY
卷 45, 期 4, 页码 369-393出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/1040841X.2019.1608905
关键词
Chemotherapy-induced peripheral neuropathy; neuropathic pain; gut microbiota; immune system; nervous system
类别
资金
- Liaoning Province Key Research and Development Project Critical Project [2017225005]
- Shenyang Municipal Bureau of Science and Technology International Exchange and Cooperation Project [17-129-6-00]
- China Medical University High-level Innovation Team Training Plan [2017CXTD02]
Chemotherapy-induced peripheral neuropathy (CIPN) is a progressive, often irreversible condition that produces severe neurological deficits. Emerging data suggest that chemotherapy also exerts detrimental effects on gut microbiota composition and intestinal permeability, contributing to dysbiosis and inflammation. Compared with other complications associated with chemotherapy, such as diarrhoea and mucositis, CIPN is of particular concern because it is the most common reason for terminating or suspending treatment. However, specific and effective curative treatment strategies are lacking. In this review, we provide an update on current preclinical and clinical understandings about the role of gut microbiota in CIPN. The gut microbiota serves as an intersection between the microbiome-gut-brain and the neuroimmune-endocrine axis, forming a complex network that can directly or indirectly affect key components involved in the manifestations of CIPN. Herein, we discuss several potential mechanisms within the context of the networks and summarize alterations in gut microbiome induced by chemotherapeutic drugs, providing great potential for researchers to target pathways associated with the gut microbiome and overcome CIPN.
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