4.7 Article

Application of tungsten disulfide quantum dot-conjugated antimicrobial peptides in bio-imaging and antimicrobial therapy

期刊

COLLOIDS AND SURFACES B-BIOINTERFACES
卷 176, 期 -, 页码 360-370

出版社

ELSEVIER
DOI: 10.1016/j.colsurfb.2019.01.020

关键词

Anti-biofilm; Antimicrobial peptide; Ion channel; Peptide NMR; Quantum dots

资金

  1. Science and Engineering Research Board, Department of Science and Technology, Govt of India [EMR/2017/003457]
  2. India-Swedish (DST-VR) Programme of Cooperation in Science Technology [2015-06720]
  3. Department of Science and Technology [IFA 13-MS-09]
  4. Bose Institute, India
  5. LEO Foundation [LF15007] Funding Source: researchfish
  6. Swedish Research Council [2015-06720] Funding Source: Swedish Research Council

向作者/读者索取更多资源

Two-dimensional (2D) tungsten disulfide (WS2) quantum dots offer numerous promising applications in materials and optoelectronic sciences. Additionally, the catalytic and photoluminescence properties of ultra-small WS2 nanoparticles are of potential interest in biomedical sciences. Addressing the use of WS2 in the context of infection, the present study describes the conjugation of two potent antimicrobial peptides with WS2 quantum dots, as well as the application of the resulting conjugates in antimicrobial therapy and bioimaging. In doing so, we determined the three-dimensional solution structure of the quantum dot-conjugated antimicrobial peptide by a series of high-resolution nuclear magnetic resonance (NMR) techniques, correlating this to the disruption of both model lipid and bacterial membranes, and to several key biological performances, including antimicrobial and anti-biofilm effects, as well as cell toxicity. The results demonstrate that particle conjugation enhances the antimicrobial and anti-biofilm potency of these peptides, effects inferred to be due to multi-dendate interactions for the conjugated peptides. As such, our study provides information on the mode-of-action of such conjugates, laying the foundation for their potential use in treatment and monitoring of infections.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.7
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据