期刊
CLINICAL THERAPEUTICS
卷 41, 期 6, 页码 1013-1019出版社
ELSEVIER
DOI: 10.1016/j.clinthera.2019.03.015
关键词
emergency medical services; epidemiology; evidence-based medicine; out-of-hospital cardiac arrest; resuscitation; sex and gender
资金
- National Institutes of Health [5K08HL130546, 5K23HL138164]
Sex- and gender-based differences are emerging as clinically significant in the epidemiology and resuscitation of patients with out-of-hospital cardiac arrest (OHCA). Female patients tend to be older, experience arrest in private locations, and have fewer initial shockable rhythms (ventricular fibrillation/ventricular tachycardia). Despite standardized algorithms for the management of OHCA, women are less likely to receive evidence-based interventions, including advanced cardiac life support medications, percutaneous coronary intervention, and targeted temperature management. While some data suggest a protective mechanism of estrogen in the heart, brain, and kidney, its role is incompletely understood. Female patients experience higher mortality from OHCA, prompting the need for sex-specific research. (C) 2019 Published by Elsevier Inc.
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