期刊
CLINICAL RHEUMATOLOGY
卷 39, 期 1, 页码 27-36出版社
SPRINGER LONDON LTD
DOI: 10.1007/s10067-019-04564-8
关键词
Digital ulcer; Management; Systemic sclerosis
类别
资金
- National Institutes of Health Research (NIHR) [CDF-2014-07-051] Funding Source: National Institutes of Health Research (NIHR)
- Department of Health [CDF-2014-07-051] Funding Source: Medline
- European Community's Framework Programme 7 [305495] Funding Source: Medline
Introduction DeSScipher is the first European multicentre study on management of systemic sclerosis (SSc), and its observational trial 1 (OT1) evaluated the efficacy of different drugs for digital ulcer (DU) prevention and healing. The aim of this study was to assess current use of vasoactive/vasodilating agents for SSc-related DU in the expert centres by analysing the baseline data of the DeSScipher OT1. Method Baseline characteristics of patients enrolled in the OT1 and data regarding DU were analysed. Results The most commonly used drugs, in both patients with and without DU, were calcium channel blockers (CCBs) (71.6%), followed by intravenous iloprost (20.8%), endothelin receptor antagonists (ERAs) (20.4%) and phosphodiesterase 5 (PDE-5) inhibitors (16.5%). Of patients, 32.6% with DU and 12.8% without DU received two drugs (p < 0.001), while 11.5% with DU and 1.9% without DU were treated with a combination of three or more agents (p < 0.001). Sixty-five percent of the patients with recurrent DU were treated with bosentan and/or sildenafil. However, 64 out of 277 patients with current DU (23.1%) and 101 (23.6%) patients with recurrent DU were on CCBs alone. Conclusions Our study shows that CCBs are still the most commonly used agents for DU management in SSc. The proportion of patients on combination therapy was low, even in patients with recurrent DU: almost one out of four patients with current and recurrent DU was on CCBs alone. Prospective analysis is planned to investigate the efficacy of different drugs/drug combinations on DU healing and prevention.
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