期刊
CLINICAL AND EXPERIMENTAL OPTOMETRY
卷 102, 期 4, 页码 350-363出版社
TAYLOR & FRANCIS LTD
DOI: 10.1111/cxo.12918
关键词
biomarkers; comfort; contact lenses; tear film
资金
- Australian Research Council [C00002330, C00107184, C00107348, RN0460002, LP0669178, LP0774951, LE0882855, LP0989883, LE0989078, DP1094624, LP110100384, LE120100059, LP140100711]
- Cooperative Research Centre for Eye Research and Technology
- Vision Cooperative Research Centre
- Dairy Australia
- University of New South Wales
- Optometric Vision Research Foundation
- American Academy of Optometry
- Vistakon and division of Johnson and Johnson Vision Care
- Allergan Inc.
- Alcon Laboratories (and CIBA Vision)
- CooperVision
- Brien Holden Vision Institute
- Australian Research Council [RN0460002, LP0669178, LP0774951, LE0882855, LP0989883, LE0989078, DP1094624, LP110100384, LE120100059, LP140100711] Funding Source: Australian Research Council
This article summarises research undertaken since 1993 in the Willcox laboratory at the University of New South Wales, Sydney on the tear film, its interactions with contact lenses, and the use of tears as a source of biomarkers for ocular and non-ocular diseases. The proteome, lipidome and glycome of tears all contribute to important aspects of the tear film, including its structure, its ability to defend the ocular surface against microbes and to help heal ocular surface injuries. The tear film interacts with contact lenses in vivo and interactions between tears and lenses can affect the biocompatibility of lenses, and may be important in mediating discomfort responses during lens wear. Suggestions are made for follow-up research.
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