期刊
CIRCULATION RESEARCH
卷 124, 期 11, 页码 1568-1583出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1161/CIRCRESAHA.118.313578
关键词
biopsy; cardiomyopathies; heart; inflammation; myocarditis
资金
- Berlin-Brandenburg Center for Regenerative Therapies-BCRT (Bundesministerium fur Bildung und Forschung) [0313911]
- Friede Springer Stiftung
- DZHK
Myocarditis is generally a mild and self-limited consequence of systemic infection of cardiotropic viruses. However, patients can develop a temporary or permanent impairment of cardiac function including acute cardiomyopathy with hemodynamic compromise or severe arrhythmias. In this setting, specific causes of inflammation are associated with variable risks of death and transplantation. Recent translational studies suggest that treatments tailored to specific causes of myocarditis may impact clinical outcomes when added to guideline-directed medical care. This review summarizes recent advances in translational research that influence the utility of endomyocardial biopsy for the management of inflammatory cardiomyopathies. Emerging therapies for myocarditis based on these mechanistic hypotheses are entering clinical trials and may add to the benefits of established heart failure treatment.
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