期刊
CHEMOSPHERE
卷 232, 期 -, 页码 171-179出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.chemosphere.2019.05.159
关键词
Tricyclazole; Hepatotoxicity; Oxidative stress; Metabolism disorder; Zebrafish
资金
- National Natural Science Foundation of China [81560109, 31771606]
- Natural Science Foundation Project of Jiangxi Province [2018ABC21033]
- Science and Technology Foundation of the Education Department of Jiangxi Province [GJJ150759]
- China Postdoctoral Foundation [2019M652269]
- Jinggangshan University [JZB15006, JFD1802]
Tricyclazole is widely used in agriculture as a pesticide, but its toxicity in vertebrates is currently poorly evaluated. In this study, we used zebrafish to assess the toxicity of tricyclazole. We found that tricyclazole induces liver damage, or hepatotoxicity, in zebrafish, during both development and adulthood. In embryos, we found that tricyclazole affected the liver development rather than other endodermal tissues such as gut and pancreas. In both embryos and adult zebrafish livers, tricyclazole disrupted the relationship between oxidant and antioxidant system and resulted in reactive oxygen species (ROS) overload. Meanwhile, it triggered hepatocyte apoptosis and disturbed carbohydrate/lipid metabolism and energy demand systems. These results suggested that tricyclazole could cause severe consequences for vertebrate hepatic development and function. (C) 2019 Elsevier Ltd. All rights reserved.
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