期刊
CHEMOSPHERE
卷 232, 期 -, 页码 232-242出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.chemosphere.2019.05.164
关键词
Analysis of pharmaceuticals in soil; Pharmaceuticals in the environment; Pharmaceuticals in soil; Soil analysis; Soil pollution
资金
- Polish Ministry of Research and Higher Education [DS 530-8610-D504-18]
- National Center for Research and Development (NCBR) (Poland) [TANGO1/268806/NCBR/2015]
In this paper, an analytical method for the simultaneous determination of twenty pharmaceuticals (eight non-steroidal anti-inflammatory drugs, five oestrogenic hormones, two antiepileptic drugs, two beta-blockers, and three antidepressants) in soils was developed. The optimal method included ultrasound assisted extraction, a clean-up step on a silica gel column, derivatization using N,O-bis(trimethylsilyl) trifluoroacetamide (BSTFA) and 1% trimethylchlorosilane (TMCS) in pyridine and ethyl acetate (2:1:1, v/v/v) for 30 min at 60 degrees C, and determination by gas chromatography-mass spectrometry working in the selected ion monitoring mode. This affords good resolution, high sensitivity and reproducibility, and freedom from interferences even from complex matrices such as soils. The method detection limits ranged from 0.3 to 1.7 ng g(-1), the intra-day precision represented as RSD5 ranged from 1.1 to 10.0%, and the intra-day accuracy from 813 to 119.7%. The absolute recoveries of the target compounds were above 80%, except for valproic acid and diethylstilbestrol. The developed method was successfully applied in the analysis of the target compounds in soils collected in Poland. Among the 20 pharmaceuticals, 12 compounds were detected at least once in the soils. The determination of antiepileptic drugs, beta-blockers, and antidepressants was also performed for the first time. (C) 2019 Elsevier Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据