期刊
CHEMOSPHERE
卷 220, 期 -, 页码 185-194出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.chemosphere.2018.12.109
关键词
Bisphenols; Toxicokinetics; Pregnancy; Fetal exposure
资金
- National Institute of Environmental Health Sciences (NIEHS) of the National Institute of Health (NIH) [1K22ES026208, R01 ES027863]
- MSU AgBioResearch
- United States Department of Agriculture (USDA) National Institute of Food and Agriculture [MICL02383]
- BioMolecular Sciences graduate program at MSU
- Environmental and Integrative Toxicological Sciences (EITS) of the Institute for Integrative Toxicology at MSU
- MSU Office of the Vice President for Research and Graduate Studies, AgBioResearch, College of Graduate Studies, and College of Human Medicine
- Michigan State University (MSU)
Bisphenol A (BPA), S (BPS), and F (BPF) are among the most abundant bisphenols detected in humans, yet pregnancy toxicokinetics for BPS or BPF remain unknown. Because gestational BPS can disrupt placental function and result in reproductive and metabolic disorders in the progeny, the aim of the study was to investigate BPS and BPF toxicokinetics during pregnancy using an in vivo approach. Fetal catheterizations were conducted in pregnant sheep (n = 6) at mid-pregnancy and injected with either a single dose of BPS (n = 3, 0.5 mg/kg, s.c.), or a combination of BPS, BPF, and BPA (n = 3, 0.5 mg/kg for each chemical, s.c.). Maternal and fetal blood and urine and amniotic fluid were collected over 72 h and analyzed for bisphenols by HPLC-MS/MS. We observed significant differences in half-life, maximum concentration, and total body clearance in maternal circulation among bisphenols. Longer half-lives were observed in fetal vs. maternal circulation for all bisphenols. Fetal toxicokinetics differed among bisphenols with BPS having the longest fetal half-life. All bisphenols reached basal levels at 48 h in maternal plasma, but were still detectable in amniotic fluid, fetal urine, and fetal plasma at 72 h. In this first pregnancy toxicokinetic study of BPS and BPF we have demonstrated maternal and fetal toxicokinetic differences among all three bisphenols. Higher BPS persistence in the fetal compartment warrants studies into progeny adverse outcomes following gestational exposure. Additionally, toxicokinetic differences among bisphenols call for a more careful approach when extrapolating kinetic information from one bisphenol chemical to another. (C) 2018 Elsevier Ltd. All rights reserved.
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