期刊
CHEMISTRY-A EUROPEAN JOURNAL
卷 25, 期 22, 页码 5677-5681出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201901020
关键词
chiral phosphoric acid; indoles; nucleophilic addition; pyrroles; trifluoromethyl ketimine
资金
- MEXT, Japan
- JSPS [17H03060]
- Grants-in-Aid for Scientific Research [17H03060] Funding Source: KAKEN
An enantioselective Friedel-Crafts alkylation reaction of pyrroles and indoles with N-unprotected trifluoromethyl ketimines by use of chiral phosphoric acid provided alpha-trifluoromethylated primary amines bearing chiral tetrasubstituted carbon centers in high yields and with high to excellent enantioselectivities. The present reaction is unique to N-unprotected trifluoromethyl ketimines. No reaction took place with N-p-methoxyphenyl (PMP)-substituted ketimine. Corresponding alpha-trifluoromethylated amines were transformed without loss of enantioselectivity.
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