期刊
CHEMISTRY OF MATERIALS
卷 31, 期 11, 页码 3948-3956出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.chemmater.9b00150
关键词
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资金
- Natural Science Foundation Committee of China [NSFC 81671803]
- National Key Research and Development Program [2017YFC0107700]
- Outstanding Youth Foundation of Jiangsu Province [GX20171114003, BK20170030]
- Fok Ying Tung Education Foundation [GX20180528002]
- Double First-Class University project [CPU2018GY24, CPU2018GY06]
- Priority Academic Program Development of Jiangsu Higher Education Institutions
Conventional chemotherapeutic drugs cause systemic side effects due to nonspecific interactions with healthy tissues, which significantly hinders their tolerability and efficacy. Herein, we developed an intelligent drug delivery system, in which the drug release can be triggered by near infrared (NIR) light at the tumor locus, prohibiting damage to normal tissues. This light-responsive system was established based on lipid nanoparticles consisting of a eutectic mixture of lauric acid and stearic acid, which have a melting point at 39 degrees C. Anticancer drug doxorubicin and NIR-absorbing dye methylenebisacrylamide were coencapsulated into these nanoparticles, while cRGD and CD47 peptide were conjugated on their surfaces for tumor targeting and immune evasion. The resultant nanoparticles exhibited quick drug release in response to NIR irradiation, prominent photothermal effects, and good cancer targeting ability. Furthermore, in vivo studies in multiple tumor models all showed that the nanoparticles could specifically accumulate at the tumor site and drastically reduce tumor size without systemic side effects, demonstrating the promising potential of this intelligent drug delivery system for future cancer treatment.
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