期刊
CHEMISTRY & BIODIVERSITY
卷 16, 期 6, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cbdv.201900052
关键词
starfish-derived symbiotic fungus; Penicillium sp; GGF16-1-2; enantiomers; antibacterial activity; cytotoxicity; inhibitors
资金
- NSFC [81741160]
- Science and Technology Planning Project of Guangdong Province [2015A020216017, 2017A020217008]
- Natural Science Foundation of Guangdong Province [2014A030313411]
- Fire Plan Project of the Guangzhou University of Chinese Medicine [XH20170110]
- Open Subject of State Key Laboratory of Marine Resources Utilization in the South China Sea of Hainan University [2016003]
- Open Subject of Guangdong Province Key Laboratory of Pharmacodynamic Constituents of Traditional Chinese Medicine and New Drugs Research
One new racemic mixture, penicilliode A (1) and four pairs of enantiomeric polyketides, penicilliode B and C (2 and 3) and coniochaetone B and C (4 and 5), were obtained from the starfish-derived symbiotic fungus Penicillium sp. GGF16-1-2. Interestingly, the strain GGF16-1-2 can produce enantiomers. The absolute configuration of 1 was determined by X-ray diffraction (XRD) analysis, and the absolute configurations of 2-4 were determined by the optical rotation (OR) values and electronic circular dichroism (ECD) calculations. Compounds 1-5 were firstly isolated from the marine-derived fungus Penicillium as racemates, and 2-5 were separated by HPLC with a chiral stationary phase. All the compounds were evaluated for their antibacterial, cytotoxic and inhibitory activities against PDE4D2.
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