期刊
CHEMICO-BIOLOGICAL INTERACTIONS
卷 303, 期 -, 页码 90-97出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.cbi.2019.02.027
关键词
3 beta-hydroxysteroid dehydrogenase; Testosterone production; Steroidogenesis; Environmental endocrine disruptors; Polyphenols; Phthalates
资金
- Natural Science Foundation of China [81730042, 81601266]
- Department of Health of Zhejiang Province [2017KY483, 11-CX29]
- Wenzhou Bureau of Science and Technology [ZS2017009]
Testicular 3 beta-hydroxysteroid dehydrogenase (HSD3B) is a steroidogenic enzyme, catalyzing the conversion of 3 beta-hydroxysteroids into 3-keto-steroids. Two distinct isoforms in the human are cloned, HSD3B1 and HSD3B2, and HSD3B2 is located in the testis. HSD3B2 is a two-substrate enzyme, which binds to cofactor NAD(+) and a 3 beta-steroid. Many endocrine disruptors, including industrial compounds (phthalates, bisphenols, and perfluoroalkyl substances), insecticides and biocides (organochlorine insecticides and organotins), food additives (butylated hydroxyanisole, resveratrol, gossypol, flavones, and isoflavones), and drugs (etomidate, troglitazone, medroxyprogesterone acetate, and ketoconazole) inhibit testicular HSD3B, possibly interfering with androgen synthesis. In this review, we discuss the distinct testicular isoform of HSD3B, its gene, chemistry, subcellular location, and the endocrine disruptors that directly inhibit testicular HSD3B and their inhibitory modes.
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