期刊
CELLULAR & MOLECULAR BIOLOGY LETTERS
卷 24, 期 -, 页码 -出版社
BMC
DOI: 10.1186/s11658-019-0155-z
关键词
Colorectal cancer; microRNA107 (miR-107); Cancer progress; Transferrin receptor 1 (TFR1)
BackgroundWhile microRNAs (miRNAs) are known to play a critical role in the progression of colorectal cancer, the role of miR-107 remains unknown. We evaluated its role and explored the underlying mechanism.Materials & methodsMTT, wound-healing, transwell migration and transwell invasion assays were performed to evaluate the role of miR-107 in SW629 cell proliferation, migration and invasion. Real time-PCR and dual-luciferase reporter gene, TFR1 overexpression and western blotting assays were used to explore the underlying mechanism.ResultsMiR-107 is downregulated in colorectal cancer tissues and several human colorectal cancer cell lines. Low miR-107 expression often indicates a poor survival rate for colorectal cancer patients. MiR-107 suppresses the proliferation, migration and invasion of SW620 cells by negatively regulating transferrin receptor 1 (TFR1).ConclusionMiR-107 suppresses the metastasis of colorectal cancer and could be a potential therapy target in colorectal cancer patients.
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