期刊
CELL HOST & MICROBE
卷 25, 期 5, 页码 681-+出版社
CELL PRESS
DOI: 10.1016/j.chom.2019.03.004
关键词
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资金
- German Research Foundation (DFG) Priority Programme [SPP1656, DFG STE 1971/4-2, 1971/4-2]
- BMBF (Medizinische Infektionsgenomik)
- German Center for Infection Research (DZIF)
- Center for Gastrointestinal Microbiome Research (CEGIMIR)
- D-A-CH project (Austrian Science Fund) [I 2320-B22/DFG STE 1971/7-1]
- Swedish Research Council [2012-262, 2015-00635]
- Swedish Foundation for Strategic Research [ICA16-0031]
- Austrian Science Fund (FWF) [P26127-B20, P27831-B28]
- European Research Council [FunKeyGut 741623]
- Gebert Ruf Foundation [GRS073/17]
- Swiss National Science Foundation [20B2-1_180953]
- Austrian Science Fund (FWF) [P27831] Funding Source: Austrian Science Fund (FWF)
- Swiss National Science Foundation (SNF) [20B2-1_180953] Funding Source: Swiss National Science Foundation (SNF)
- Swedish Research Council [2015-00635] Funding Source: Swedish Research Council
- Swedish Foundation for Strategic Research (SSF) [ICA16-0031] Funding Source: Swedish Foundation for Strategic Research (SSF)
The microbiota and the gastrointestinal mucus layer play a pivotal role in protection against non-typhoidal Salmonella enterica serovar Typhimurium (S. Tm) colitis. Here, we analyzed the course of Salmonella colitis in mice lacking a functional mucus layer in the gut. Unexpectedly, in contrast to mucus-proficient littermates, genetically deficient mice were protected against Salmonellainduced gut inflammation in the streptomycin colitis model. This correlated with microbiota alterations and enrichment of the bacterial phylum Deferribacteres. Using gnotobiotic mice associated with defined bacterial consortia, we causally linked Mucispirillum schaedleri, currently the sole known representative of Deferribacteres present in the mammalian microbiota, to host protection against S. Tm colitis. Inhibition by M. schaedleri involves interference with S. Tm invasion gene expression, partly by competing for anaerobic electron acceptors. In conclusion, this study establishes M. schaedleri, a core member of the murine gut microbiota, as a key antagonist of S. Tm virulence in the gut.
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