期刊
CELL BIOLOGY INTERNATIONAL
卷 43, 期 7, 页码 739-748出版社
WILEY
DOI: 10.1002/cbin.11157
关键词
microtubules; randomness; system biology
类别
Microtubules (MTs) play roles in regulating the mechanical structure and dynamics of cells. While MTs appear to be highly ordered structures, recent data suggest some randomness in their structure and dynamics. Part of this inherent randomness is attributed to errors and correction mechanisms are being investigated to overcome these 'mistakes.' However, this randomness may also be part of the normal intracellular function of MTs. It is possible that random events in MT structure and dynamics may contribute to their normal function and may even be part of an improved efficacy mechanism. An alternative view, wherein MT and kinetochore errors are part of required cell plasticity, is also discussed. These data may further support the concept of randomness in biological pathways as part of self-organization or accurate and enhanced function.
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