相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。Therapeutic Potential of Targeting PI3K/AKT Pathway in Treatment of Colorectal Cancer: Rational and Progress
Afsane Bahrami et al.
JOURNAL OF CELLULAR BIOCHEMISTRY (2018)
Discovery and characterization of highly potent and selective allosteric USP7 inhibitors
Gerald Gavory et al.
NATURE CHEMICAL BIOLOGY (2018)
Deubiquitylating enzymes and drug discovery: emerging opportunities
Jeanine A. Harrigan et al.
NATURE REVIEWS DRUG DISCOVERY (2018)
Targeting the PI3K/AKT/mTOR pathway in triple-negative breast cancer: a review
Ricardo L. B. Costa et al.
BREAST CANCER RESEARCH AND TREATMENT (2018)
Cancer Statistics, 2018
Rebecca L. Siegel et al.
CA-A CANCER JOURNAL FOR CLINICIANS (2018)
FOXO Transcription Factors Both Suppress and Support Breast Cancer Progression
Marten Hornsveld et al.
CANCER RESEARCH (2018)
Targeting ubiquitin specific protease 7 in cancer: A deubiquitinase with great prospects
Farjana Yeasmin Khusbu et al.
CELL BIOCHEMISTRY AND FUNCTION (2018)
Improving combination cancer therapy: the CombiPlex((R)) development platform
Anthony W. Tolcher et al.
FUTURE ONCOLOGY (2018)
The androgen receptor malignancy shift in prostate cancer
Ben T. Copeland et al.
PROSTATE (2018)
Effect of FAK inhibitor VS-6063 (defactinib) on docetaxel efficacy in prostate cancer
Hui-Ming Lin et al.
PROSTATE (2018)
USP2a Supports Metastasis by Tuning TGF-beta Signaling
Yin Zhao et al.
CELL REPORTS (2018)
FOXO Signaling Pathways as Therapeutic Targets in Cancer
Mohd Farhan et al.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2017)
Ubiquitin-specific protease 8 is a novel prognostic marker in early-stage lung adenocarcinoma
Yunjung Kim et al.
PATHOLOGY INTERNATIONAL (2017)
Proteasome-associated deubiquitinase ubiquitin-specific protease 14 regulates prostate cancer proliferation by deubiquitinating and stabilizing androgen receptor
Yuning Liao et al.
CELL DEATH & DISEASE (2017)
Epithelial-mesenchymal transition in prostate cancer: an overview
Micaela Montanari et al.
ONCOTARGET (2017)
Aurora-A regulates autophagy through the Akt pathway in human prostate cancer
Shiying Zhang et al.
CANCER BIOMARKERS (2017)
USP26 regulates TGF-β signaling by deubiquitinating and stabilizing SMAD7
Sarah Kit Leng Lui et al.
EMBO REPORTS (2017)
The p53 Pathway: Origins, Inactivation in Cancer, and Emerging Therapeutic Approaches
Andreas C. Joerger et al.
ANNUAL REVIEW OF BIOCHEMISTRY, VOL 85 (2016)
Small Molecule Inhibition of the Ubiquitin-specific Protease USP2 Accelerates cyclin D1 Degradation and Leads to Cell Cycle Arrest in Colorectal Cancer and Mantle Cell Lymphoma Models
Mindy I. Davis et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2016)
Targeting persistent androgen receptor signaling in castration-resistant prostate cancer
Laura Graham et al.
MEDICAL ONCOLOGY (2016)
Molecular Pathways: Fatty Acid Synthase
Suzanne F. Jones et al.
CLINICAL CANCER RESEARCH (2015)
Deubiquitinases and the new therapeutic opportunities offered to cancer
Roland Pfoh et al.
ENDOCRINE-RELATED CANCER (2015)
The Deubiquitinating Enzyme USP7 Regulates Androgen Receptor Activity by Modulating Its Binding to Chromatin
Shu-Ting Chen et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2015)
OTUB1 de-ubiquitinating enzyme promotes prostate cancer cell invasion in vitro and tumorigenesis in vivo
Diego Iglesias-Gato et al.
MOLECULAR CANCER (2015)
UCHL1 provides diagnostic and antimetastatic strategies due to its deubiquitinating effect on HIF-1α
Yoko Goto et al.
NATURE COMMUNICATIONS (2015)
Ubiquitin-specific protease 12 interacting partners Uaf-1 and WDR20 are potential therapeutic targets in prostate cancer
Urszula L. McClurg et al.
ONCOTARGET (2015)
Ubiquitin C-terminal hydrolase-L3 regulates EMT process and cancer metastasis in prostate cell lines
Hyun Min Song et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2014)
A novel small molecule inhibitor of deubiquitylating enzyme USP14 and UCHL5 induces apoptosis in multiple myeloma and overcomes bortezomib resistance
Ze Tian et al.
BLOOD (2014)
USP22 Regulates Oncogenic Signaling Pathways to Drive Lethal Cancer Progression
Randy S. Schrecengost et al.
CANCER RESEARCH (2014)
Ubiquitination involved enzymes and cancer
Mei-juan Zhou et al.
MEDICAL ONCOLOGY (2014)
The mitotic kinase Aurora-A promotes distant metastases by inducing epithelial-to-mesenchymal transition in ERα+ breast cancer cells
A. B. D'Assoro et al.
ONCOGENE (2014)
Colon cancer bears overexpression of OTUB1
Xin Liu et al.
PATHOLOGY RESEARCH AND PRACTICE (2014)
Ubiquitin Specific Protease 26 (USP26) Expression Analysis in Human Testicular and Extragonadal Tissues Indicates Diverse Action of USP26 in Cell Differentiation and Tumorigenesis
Matthew S. Wosnitzer et al.
PLOS ONE (2014)
Aurora-A Mitotic Kinase Induces Endocrine Resistance through Down-Regulation of ERα Expression in Initially ERα plus Breast Cancer Cells
Mateusz Opyrchal et al.
PLOS ONE (2014)
Ablation of the oncogenic transcription factor ERG by deubiquitinase inhibition in prostate cancer
Shan Wang et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)
Deubiquitinating enzyme Usp12 regulates the interaction between the androgen receptor and the Akt pathway
Urszula L. McClurg et al.
ONCOTARGET (2014)
Regulation of TGF-β Superfamily Signaling by SMAD Mono-Ubiquitination
Feng Xie et al.
Cells (2014)
USP8 Is a Novel Target for Overcoming Gefitinib Resistance in Lung Cancer
Sanguine Byun et al.
CLINICAL CANCER RESEARCH (2013)
Deubiquitinating Enzyme Usp12 Is a Novel Co-activator of the Androgen Receptor
Urszula L. Burska et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2013)
Androgen receptor in human prostate cancer-associated fibroblasts promotes prostate cancer epithelial cell growth and invasion
Shengqiang Yu et al.
MEDICAL ONCOLOGY (2013)
An Immunohistochemical Signature Comprising PTEN, MYC, and Ki67 Predicts Progression in Prostate Cancer Patients Receiving Adjuvant Docetaxel After Prostatectomy
Emmanuel S. Antonarakis et al.
CANCER (2012)
Activation of Ras/PI3K/ERK Pathway Induces c-Myc Stabilization to Upregulate Argininosuccinate Synthetase, Leading to Arginine Deiminase Resistance in Melanoma Cells
Wen-Bin Tsai et al.
CANCER RESEARCH (2012)
USP22 Acts as an Oncogene by the Activation of BMI-1-Mediated INK4a/ARF Pathway and Akt Pathway
Yan-Long Liu et al.
CELL BIOCHEMISTRY AND BIOPHYSICS (2012)
Discovery of Specific Inhibitors of Human USP7/HAUSP Deubiquitinating Enzyme
Celine Reverdy et al.
CHEMISTRY & BIOLOGY (2012)
The ubiquitin hydrolase USP22 contributes to 3′-end processing of JAK-STAT-inducible genes
Edmond Chipumuro et al.
FASEB JOURNAL (2012)
Targeting Deubiquitinases Enabled by Chemical Synthesis of Proteins
Shimrit Ohayon et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2012)
USP15 stabilizes TGF-β receptor I and promotes oncogenesis through the activation of TGF-β signaling in glioblastoma
Pieter J. A. Eichhorn et al.
NATURE MEDICINE (2012)
Selective Dual Inhibitors of the Cancer-Related Deubiquitylating Proteases USP7 and USP47
Joseph Weinstock et al.
ACS MEDICINAL CHEMISTRY LETTERS (2012)
MYC Is Activated by USP2a-Mediated Modulation of MicroRNAs in Prostate Cancer
Barbara Benassi et al.
CANCER DISCOVERY (2012)
PI3K-AKT-FoxO axis in cancer and aging Preface
Guri Tzivion et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2011)
FoxO transcription factors; Regulation by AKT and 14-3-3 proteins
Guri Tzivion et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2011)
Akt, FoxO and regulation of apoptosis
Xinbo Zhang et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2011)
UCH-L1 promotes cancer metastasis in prostate cancer cells through EMT induction
Min Jung Jang et al.
CANCER LETTERS (2011)
Beclin1 Controls the Levels of p53 by Regulating the Deubiquitination Activity of USP10 and USP13
Junli Liu et al.
CELL (2011)
The Differential Modulation of USP Activity by Internal Regulatory Domains, Interactors and Eight Ubiquitin Chain Types
Alex C. Faesen et al.
CHEMISTRY & BIOLOGY (2011)
Pharmacological targets in the ubiquitin system offer new ways of treating cancer, neurodegenerative disorders and infectious diseases
Mariola J. Edelmann et al.
EXPERT REVIEWS IN MOLECULAR MEDICINE (2011)
Ubiquitin-specific Cysteine Protease 2a (USP2a) Regulates the Stability of Aurora-A
Yan Shi et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2011)
USP10 deubiquitylates the histone variant H2A.Z and both are required for androgen receptor-mediated gene activation
Ryan Draker et al.
NUCLEIC ACIDS RESEARCH (2011)
Identification of Distinctive Patterns of USP19-Mediated Growth Regulation in Normal and Malignant Cells
Yu Lu et al.
PLOS ONE (2011)
TMPRSS2-ERG Gene Fusion Prevalence and Class Are Significantly Different in Prostate Cancer of Caucasian, African-American and Japanese Patients
Cristina Magi-Galluzzi et al.
PROSTATE (2011)
Deubiquitinase Inhibition by Small-Molecule WP1130 Triggers Aggresome Formation and Tumor Cell Apoptosis
Vaibhav Kapuria et al.
CANCER RESEARCH (2010)
Single-Nucleotide Polymorphisms in p53 Pathway and Aggressiveness of Prostate Cancer in a Caucasian Population
Tong Sun et al.
CLINICAL CANCER RESEARCH (2010)
Fatty acid synthase as a potential therapeutic target in cancer
Richard Flavin et al.
FUTURE ONCOLOGY (2010)
The Deubiquitinating Enzyme USP26 Is a Regulator of Androgen Receptor Signaling
Annette M. G. Dirac et al.
MOLECULAR CANCER RESEARCH (2010)
The de-ubiquitinase UCH-L1 is an oncogene that drives the development of lymphoma in vivo by deregulating PHLPP1 and Akt signaling
S. Hussain et al.
LEUKEMIA (2010)
Ezrin mediates c-Myc actions in prostate cancer cell invasion
Y-C Chuan et al.
ONCOGENE (2010)
Treatment-Dependent Androgen Receptor Mutations in Prostate Cancer Exploit Multiple Mechanisms to Evade Therapy
Mara P. Steinkamp et al.
CANCER RESEARCH (2009)
ERG Is a Megakaryocytic Oncogene
Samira Salek-Ardakani et al.
CANCER RESEARCH (2009)
Increased Expression of Androgen Receptor Sensitizes Prostate Cancer Cells to Low Levels of Androgens
Kati K. Waltering et al.
CANCER RESEARCH (2009)
FAM/USP9x, a Deubiquitinating Enzyme Essential for TGFβ Signaling, Controls Smad4 Monoubiquitination
Sirio Dupont et al.
CELL (2009)
TGFβ family signaling: novel insights in development and disease
Kristi Wharton et al.
DEVELOPMENT (2009)
Prostate Specific Antigen Best Practice Statement: 2009 Update
Kirsten L. Greene et al.
JOURNAL OF UROLOGY (2009)
USP19 Deubiquitinating Enzyme Supports Cell Proliferation by Stabilizing KPC1, a Ubiquitin Ligase for p27Kip1
Yu Lu et al.
MOLECULAR AND CELLULAR BIOLOGY (2009)
Small-molecule inhibitor of USP7/HAUSP ubiquitin protease stabilizes and activates p53 in cells
Frederic Colland et al.
MOLECULAR CANCER THERAPEUTICS (2009)
TMPRSS2-ERG and PTEN loss in prostate cancer
Jeremy A. Squire
NATURE GENETICS (2009)
Aberrant ERG expression cooperates with loss of PTEN to promote cancer progression in the prostate
Brett S. Carver et al.
NATURE GENETICS (2009)
Breaking the chains: structure and function of the deubiquitinases
David Komander et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2009)
Ubiquitin C-terminal hydrolase-L1 is a key regulator of tumor cell invasion and metastasis
H. J. Kim et al.
ONCOGENE (2009)
Expression and Functional Studies of Ubiquitin C-Terminal Hydrolase L1 Regulated Genes
Anjali Bheda et al.
PLOS ONE (2009)
The nuclear affairs of PTEN
Sarah M. Planchon et al.
JOURNAL OF CELL SCIENCE (2008)
Fatty acid synthase and AKT pathway signaling in a subset of papillary thyroid cancers
Shahab Uddin et al.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2008)
Nuclear MYC protein overexpression is an early alteration in human prostate carcinogenesis
Bora Gurel et al.
MODERN PATHOLOGY (2008)
The putative cancer stem cell marker USP22 is a subunit of the human SAGA complex required for activated transcription and cell-cycle progression
Xiao-Yong Zhang et al.
MOLECULAR CELL (2008)
The deubiquitinylation and localization of PTEN are regulated by a HAUSP-PML network
Min Sup Song et al.
NATURE (2008)
TMPRSS2-ERG fusion, a common genomic alteration in prostate cancer activates C-MYC and abrogates prostate epithelial differentiation
C. Sun et al.
ONCOGENE (2008)
A causal role for ERG in neoplastic transformation of prostate epithelium
Olga Klezovitch et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
The Cdk inhibitor p27 in human cancer: prognostic potential and relevance to anticancer therapy
Isabel M. Chu et al.
NATURE REVIEWS CANCER (2008)
Fatty acid synthase and the lipogenic phenotype in cancer pathogenesis
Javier A. Menendez et al.
NATURE REVIEWS CANCER (2007)
Gene fusions between TMPRSS2 and ETS family genes in prostate cancer:: frequency and transcript variant analysis by RT-PCR and FISH on paraffin-embedded tissues
Jiangling J. Tu et al.
MODERN PATHOLOGY (2007)
Loss of p53 promotes RhoA-ROCK-dependent cell migration and invasion in 3D matrices
Gilles Gadea et al.
JOURNAL OF CELL BIOLOGY (2007)
TMPRSS2: ERG gene fusion associated with lethal prostate cancer in a watchful waiting cohort
F. Demichelis et al.
ONCOGENE (2007)
The deubiquitinating enzyme USP2a regulates the p53 pathway by targeting Mdm2
Lauren F. Stevenson et al.
EMBO JOURNAL (2007)
MDM2 inhibitors for cancer therapy
Lyubomir T. Vassilev
TRENDS IN MOLECULAR MEDICINE (2007)
Molecular regulation of androgen action in prostate cancer
Scott M. Dehm et al.
JOURNAL OF CELLULAR BIOCHEMISTRY (2006)
The isopeptidase USP2a protects human prostate cancer from apoptosis
Carmen Priolo et al.
CANCER RESEARCH (2006)
TGF-β and cancer
B Bierie et al.
CYTOKINE & GROWTH FACTOR REVIEWS (2006)
A genomic and functional inventory of deubiquitinating enzymes
SMB Nijman et al.
CELL (2005)
Recurrent fusion of TMPRSS2 and ETS transcription factor genes in prostate cancer
SA Tomlins et al.
SCIENCE (2005)
Androgen receptor in prostate cancer
CA Heinlein et al.
ENDOCRINE REVIEWS (2004)
The isopeptidase USP2a regulates the stability of fatty acid synthase in prostate cancer
E Graner et al.
CANCER CELL (2004)
Mechanism and function of deubiquitinating enzymes
AY Amerik et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2004)
Discovery of inhibitors that elucidate the role of UCH-L1 activity in the H1299 lung cancer cell line
YC Liu et al.
CHEMISTRY & BIOLOGY (2003)
Myc-driven murine prostate cancer shares molecular features with human prostate tumors
K Ellwood-Yen et al.
CANCER CELL (2003)
Decision making by p53: life, death and cancer
M Oren
CELL DEATH AND DIFFERENTIATION (2003)
Nuclear PTEN expression and clinicopathologic features in a population-based series of primary cutaneous melanoma
DC Whiteman et al.
INTERNATIONAL JOURNAL OF CANCER (2002)
Deubiquitination of p53 by HAUSP is an important pathway for p53 stabilization
MY Li et al.
NATURE (2002)
Expression and functional analysis of Uch-L3 during mouse development
LJ Kurihara et al.
MOLECULAR AND CELLULAR BIOLOGY (2000)