期刊
CELL
卷 177, 期 7, 页码 1915-+出版社
CELL PRESS
DOI: 10.1016/j.cell.2019.04.040
关键词
-
资金
- Swedish Research Council
- Childhood Cancer Foundation in Sweden
- Charles A. King Trust Postdoctoral Research Fellowship Program
- Simeon J. Fortin Charitable Foundation
- Klarman Cell Observatory
- HHMI
- NIH [DK107784]
- Gerald and Darlene Jordan Professorship
Stroma is a poorly defined non-parenchymal component of virtually every organ with key roles in organ development, homeostasis and repair. Studies of the bone marrow stroma have defined individual populations in the stem cell niche regulating hematopoietic regeneration and capable of initiating leukemia. Here, we use single-cell RNA-seq to define a cellular taxonomy of the mouse bone marrow stroma and its perturbation by malignancy. We identified seventeen stromal subsets expressing distinct hematopoietic regulatory genes, spanning new fibroblastic, and osteoblastic subpopulations. Emerging acute myeloid leukemia resulted in impaired osteogenic differentiation and reduced production of hematopoietic regulatory molecules necessary for normal hematopoiesis. Thus, cancer can affect tissue stroma in which they reside to disadvantage normal parenchymal cells. Our taxonomy of the regulatory stromal compartment provides experimental support for a model where malignant clone is not a destroyer of normal tissue but an architect of it, remodeling tissue stroma to enable emergent cancer.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据