期刊
CARDIOVASCULAR RESEARCH
卷 115, 期 8, 页码 1286-1295出版社
OXFORD UNIV PRESS
DOI: 10.1093/cvr/cvz100
关键词
TAM receptors; Tyro3; Axl; MerTK; Cardiovascular disease
资金
- British Heart Foundation [PG/12/81/29897, RE/13/5/30177, FS/16/55/32731]
- Engineering and Physical Sciences Research Council (EPSRC) [EP/L014165/1]
- European Commission Marie Sklodowska-Curie Individual Fellowships [661369]
- Arthritis Research UK [RACE20298]
- National Institutes of Health [HL075662, HL127464, HL132412]
- EPSRC [EP/L014165/1] Funding Source: UKRI
The TAM receptors are a distinct family of three receptor tyrosine kinases, namely Tyro3, Axl, and MerTK. Since their discovery in the early 1990s, they have been studied for their ability to influence numerous diseases, including cancer, chronic inflammatory and autoimmune disorders, and cardiovascular diseases. The TAM receptors demonstrate an ability to influence multiple aspects of cardiovascular pathology via their diverse effects on cells of both the vasculature and the immune system. In this review, we will explore the various functions of the TAM receptors and how they influence cardiovascular disease through regulation of vascular remodelling, efferocytosis and inflammation. Based on this information, we will suggest areas in which further research is required and identify potential targets for therapeutic intervention.
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