期刊
CARBOHYDRATE POLYMERS
卷 211, 期 -, 页码 133-140出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2019.01.110
关键词
Hydroxypropyl methyl cellulose; Poly(L-lactide); Topology Self-assembly; Micelle
资金
- China Scholarship Council (CSC) [CSC No201606240124]
AB(2)-type amphiphilic (HPMC)(2)-PLA copolymers with various hydrophilic block lengths were synthesized using a three step procedure: ring-opening polymerization of L-lactide initiated by propynol, amination reduction of the aldehyde endgroup of HPMC, and thiol-click reaction. The resulted copolymers were characterized by NMR, DOSY-NMR, SEC and FT-IR. The cloud point (CP) was determined by UV-vis spectrometer. Data show that the HPMC block length has little effect on the Cp of the copolymers which is lower than that of HPMC. The self-assembly behavior of the copolymers was investigated from DLS, TEM, and critical micelle concentration (CMC) measurements. Spherical micelles are obtained by self-assembly of copolymers in aqueous solution. The micelle size and the CMC of copolymers increase with increasing HPMC block length. It is concluded that biobased and biodegradable (HPMC) 2-PLA copolymers could be promising as nano-carrier of hydrophobic drugs.
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